Cadherin-16 (CDH16) Immunohistochemistry: A Novel Diagnostic Tool for Renal Cell Carcinoma and Papillary Carcinomas of the Thyroid

Abstract Introduction/Objective Introduction: Cadherin-16 (CDH16), also termed kidney specific cadherin (ksp-cadherin), is a membrane-associated glycoprotein with role in the embryonal development of tubules and thyroid. Downregulation CDH16 RNA was found papillary carcinomas Methods/Case Report Methods: A set tissue microarrays containing 14,978 samples from 149 different tumor types subtypes as well 608 76 normal analyzed by immunohistochemistry to determine expression cancer assess diagnostic utility immunohistochemical analysis. Results (if Case Study enter NA) Results: Among tissues, membranous immunostaining predominated thyroid, kidney, cauda epididymis, mesonephric remnants. In staining seen 100% samples, 83% follicular adenomas, 58% carcinomas, but only 9% (p<0.0001). non-thyroidal tumors, positivity particularly frequent nephrogenic adenomas (100%), oncocytomas (98%), chromophobe (97%), clear cell (85%), (76%) renal (RCCs), (56%), mucinous (36%), endometroid (16%) carcinosarcomas (18%) ovary, adenocarcinomas cervix uteri (40%), serous (33%), endometrium various neuroendocrine neoplasms (4-26%). Conclusion Given massive loss >90% highly useful marker for these tumors. identification distinction other neoplasms.